Blar i forfatter "Akslen, Lars A."

Viser treff 1-4 av 4

    • Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo 

      Knappskog, Stian; Berge, Elisabet Ognedal; Chrisanthar, Ranjan; Geisler, Stephanie; Staalesen, Vidar; Leirvaag, Beryl; Yndestad, Synnøve; de Faveri, Elise Norheim; Karlsen, Bård Ove; Wedge, David C.; Akslen, Lars A.; Lilleng, Peer Kåre; Løkkevik, Erik; Lundgren, Steinar; Østenstad, Bjørn; Risberg, Terje; Mjaaland, Ingvil; Aas, Turid; Lønning, Per Eystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-08)
      Chemoresistance is the main obstacle to cancer cure. Contrasting studies focusing on single gene mutations, we hypothesize chemoresistance to be due to inactivation of key pathways affecting cellular mechanisms such as apoptosis, senescence, or DNA repair. In support of this hypothesis, we have previously shown inactivation of either TP53 or its key activators CHK2 and ATM to predict resistance ...

    • Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts 

      Lindholm, Evita Maria; Kristian, Alexandr; Nalwoga, Hawa; Kruger, Kristi; Nygård, Ståle; Akslen, Lars A.; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-31)
      Several clinical trials have investigated the efficacy of bevacizumab in breast cancer, and even if growth inhibiting effects have been registered when antiangiogenic treatment is given in combination with chemotherapy no gain in overall survival has been observed. One reason for the lack of overall survival benefit might be that appropriate criteria for selection of patients likely to respond ...

    • Exploring the effects of lifestyle on breast cancer risk, age at diagnosis, and survival: the EBBA-Life study 

      Lofterød, Trygve; Frydenberg, Hanne; Flote, Vidar Gordon; Eggen, Anne Elise; McTiernan, A; Mortensen, Elin Synnøve; Akslen, Lars A.; Reitan, J. B.; Wilsgaard, Tom; Inger, Thune (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-20)
      <i>Purpose</i> - Whether an unfavorable lifestyle not only affects breast cancer risk, but also influences age at onset of breast cancer and survival, is under debate.<br><br> <i>Methods</i> - In a population-based cohort, the Energy Balance and Breast Cancer Aspects throughout life (EBBA-Life) study, a total of 17,145 women were included. During follow-up, 574 women developed invasive breast cancer. ...

    • Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes 

      Lofterød, Trygve; Mortensen, Elin Synnøve; Nalwoga, Hawa; Wilsgaard, Tom; Frydenberg, Hanne; Risberg, Terje; Eggen, Anne Elise; McTiernan, Anne; Aziz, Sura Mohammed; Wist, Erik; Stensvold, Andreas; Reitan, Jon Brinchmann; Akslen, Lars A.; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-15)
      <i>Background</i>: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast cancer heterogeneity may explain the contradictory influence of triglycerides and cholesterol observed on breast cancer prognosis remains unclear.<p> <p><i>Methods</i>: A population-based survival study among 464 breast cancer cases ...